期刊
JOURNAL OF BIOCHEMISTRY
卷 147, 期 4, 页码 459-462出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvq013
关键词
Baculovirus; binding; haemagglutinin; influenza A virus; sulphatide
资金
- Institute for Fermentation, Osaka, Japan, Ministry of Education, Culture, Sports, Science and Technology [20790357]
- Japan Science Society
- Japan Society for the Promotion of Science
Association of sulphatide with influenza A virus (IAV) haemagglutinin (HA) delivered to the cell surface promotes progeny virus production. However, it is not known whether there is direct binding of HA to sulphatide. In this study, we found that recombinant HA, which was produced by a baculovirus protein expression system from the HA gene of A/duck/HK/313/4/78 (H5N3), bound to sulphatide in a dose-dependent manner and that the binding was inhibited by a specific antibody. Our results indicate that the recombinant HA is useful for elucidation of the binding domain of HA with sulphatide and for the development of new anti-IAV agents.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据