期刊
JOURNAL OF BIOCHEMISTRY
卷 148, 期 4, 页码 381-392出版社
OXFORD UNIV PRESS
DOI: 10.1093/jb/mvq096
关键词
biogenesis; Dicer; Drosha; processing; miRNA; microRNA
资金
- National Institute of Health [RO1 HD042149, RO1 HL082854, T32 HL069770]
- American Heart Association [0940095N]
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT [R01HD042149] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL082854, R01HL093154, T32HL069770] Funding Source: NIH RePORTER
MicroRNAs (miRNAs) are a class of similar to 22 nt non-coding RNAs that control diverse biological functions in animals, plants and unicellular eukaryotes by promoting degradation or inhibition of translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated. Aberrant expression of miRNAs has been linked to developmental abnormalities and human diseases, including cancer and cardiovascular disorders. The recent identification of mechanisms of miRNA biogenesis regulation uncovers that various factors or growth factor signalling pathways control every step of the miRNA biogenesis pathway. Here, we review the mechanisms that control the regulation of miRNA biogenesis discovered in human cells. Further understanding of the mechanisms that control of miRNA biogenesis may allow the development of tools to modulate the expression of specific miRNAs, which is crucial for the development of novel therapies for human disorders derived from aberrant expression of miRNAs.
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