4.2 Article

TRAF-Interacting Protein with a Forkhead-Associated Domain B (TIFAB) Is a Negative Regulator of the TRAF6-Induced Cellular Functions

期刊

JOURNAL OF BIOCHEMISTRY
卷 146, 期 3, 页码 375-381

出版社

OXFORD UNIV PRESS
DOI: 10.1093/jb/mvp080

关键词

cell cycle; forkhead-associated domain; NF-kappa B; TIFA; TRAF

资金

  1. Grant-in-Aid for Scientific Research on Priority Area [17014017, 18799010]
  2. Ministry of Education, Culture, Sports, Science and Technology of the Japanese government
  3. Grants-in-Aid for Scientific Research [17014017, 18799010] Funding Source: KAKEN

向作者/读者索取更多资源

Tumour necrosis factor receptor-associated factor (TRAF)-interacting protein with a forkhead-associated domain (TIFA) activates TRAF6 to induce NF-kappa B activation. TIFA-related protein, TIFAB, is highly expressed in the spleen and inhibits TIFA-mediated TRAF6 activation. However, little is known about cell types that express TIFAB and its function in those cells. Here, we show that TIFAB is mainly expressed in B cells rather than T cells in the spleen and that the expression level was much higher in dendritic cells (DCs) and macrophages than that in splenic lymphocytes. TIFAB expression was downregulated when B cells, DCs or macrophages were stimulated by TRAF6-mediated proliferative or maturation signals including those emanating from CD40, sIgM and TLRs. Furthermore, microinjection experiments using NIH3T3 cells revealed that TIFAB inhibited entry into the S phase of the cell cycle. Our results suggest that TIFAB could act as a negative regulator of the TRAF6-induced cellular function such as B cell proliferation and maturation of DCs and macrophages.

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