期刊
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 28, 期 3, 页码 274-288出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911513484572
关键词
Biodegradable; biobased monomer; polyurethane; biocompatible; isomannide
资金
- Priority Research Centers Program [2009-0093829]
- World Class University (WCU) Program through the National Research Foundation of Korea [R31-10069]
- Ministry of Education, Science, and Technology
Biodegradable-biocompatible polyurethanes were prepared with fixed hexamethylene diisocyanate and varying ratios of isomannide and poly(E-caprolactone) diol using a simple one-step polymerization without a catalyst. The polyurethane structures were confirmed by H-1-nuclear magnetic resonance, Fourier transform infrared spectroscopy, and gel permeation chromatography. The glass transition temperatures were determined by thermal analysis to be between 25 degrees C and 30 degrees C. Degradation tests performed at 37 degrees C in phosphate buffer produced mass losses of 5%-10% after 8 weeks. After 5 days of culture, using osteoblastic cells, the relative cell number on all the polyurethane films was only slightly lower than that of an optimized tissue culture plastic. These polymers offer significant promise with a simplistic synthesis and controlled degradation.
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