期刊
NATURE REVIEWS RHEUMATOLOGY
卷 11, 期 4, 页码 243-256出版社
NATURE PORTFOLIO
DOI: 10.1038/nrrheum.2015.13
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类别
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- AO Spine International
- AO Foundation
- Grants-in-Aid for Scientific Research [24592213] Funding Source: KAKEN
Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain, which accounts for disability worldwide. Despite the known outcomes of the IVD degeneration cascade, the treatment of IVD degeneration is limited in that available conservative and surgical treatments do not reverse the pathology or restore the IVD tissue. Regenerative medicine for IVD degeneration, by injection of IVD cells, chondrocytes or stem cells, has been extensively studied in the past decade in various animal models of induced IVD degeneration, and has progressed to clinical trials in the treatment of various spinal conditions. Despite preliminary results showing positive effects of cell-injection strategies for IVD regeneration, detailed basic research on IVD cells and their niche indicates that transplanted cells are unable to survive and adapt in the avascular niche of the IVD. For this therapeutic strategy to succeed, the indications for its use and the patients who would benefit need to be better defined. To surmount these obstacles, the solution will be identified only by focused research, both in the laboratory and in the clinic.
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