Poly(butylene/diethylene glycol succinate) multiblock copolyester as a candidate biomaterial for soft tissue engineering: Solid-state properties, degradability, and biocompatibility

A multiblock bioresorbable copolyester, poly(butylene/diethylene glycol succinate), was synthesized by reactive blending, and it was used, together with the corresponding poly(butylene succinate) homopolymer, to form films and to fabricate biomimetic electrospun scaffolds. The poly(butylene/diethylene glycol succinate) scaffold had a more pronounced elastomeric behavior than poly(butylene succinate). It also underwent hydrolytic degradation faster than poly(butylene succinate) since the incorporated diethylene glycol succinate units rendered the copolymer more hydrophilic than poly(butylene succinate). The films degraded faster than electrospun samples due to the autocatalytic effect of carboxylic end-groups. The biodegradable poly(butylene/diethylene glycol succinate) scaffold supported the growth and preserved the cardiac phenotype markers of H9c2 cells, demonstrating its potential utility in soft tissue engineering applications.