期刊
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 26, 期 5, 页码 478-492出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911511415918
关键词
scaffolds; tissue engineering; drug release; wet-spinning; star polymer; microfibrous meshes
资金
- European Network of Excellence [NMP3-CT-2004-500283]
Three-dimensional wet-spun microfibrous meshes of a star poly(a-caprolactone) were developed as potential scaffolds endowed with antimicrobial activity. The in vitro release kinetics of the meshes, under physiological conditions, was initially fast and then a sustained release for more than one month was observed. Cell cultures of a murine pre-osteoblast cell line showed good cell viability and adhesion on the wet-spun star poly(a-caprolactone) fiber scaffolds. These promising results indicate a potential application of the developed meshes as engineered bone scaffolds with antimicrobial activity.
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