期刊
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 25, 期 6, 页码 654-668出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911510384836
关键词
phosphorylcholine; polyester; polymer blends; biodegradability; blood compatibility; polymer-metal adhesion
资金
- Natural Science Foundation of China [NSFC-20774082, 50830106]
- 863 National High-Tech RD Program [2006AA03Z329, 2006AA03Z444]
- Major State Basic Research Foundation of China [2005CB623902]
- Science Foundation of Chinese University
- Ph.D. Programs Foundation of Ministry of Education of China [20070335024]
- Fundamental Research Funds for the Central Universities [2009QNA4039]
- Natural Science Foundation of China of Zhejiang Province [Y4080250]
To optimize the blood biocompatibility of poly(lactide-coglycolide) (PLGA), lipid-like diblock copolymer poly(DL-lactide)-blockpoly(2-methacryloyloxyethyl phosphorylcholine) (PLA-b-PMPC) was employed as a surface-modifying additive. The blends of PLGA and PLA-b-PMPC coated poly(ethylene terephthalate) membranes were prepared by dip-coating. ATR-FTIR spectroscopy showed the incorporation of phosphorylcoline groups in the blends and contact angle results indicated that the hydrophilicity of the blends improved with increasing PLA-b-PMPC content. The plasma recalcification time of polymer coating was prolonged and the amount of adherent platelets on coating surface was decreased by introducing PLA-b-PMPC. The adhesion of polymer coating on the gold electrode of quartz crystal microbalance was monitored and PLGA containing PLA-b-PMPC additives showed excellent polymer-metal adhesion. These results show that the blends of PLGA and lipid-like PLA-b-PMPC could be used as high performance biodegradable polymer coatings for blood contact medical devices.
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