期刊
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 25, 期 3, 页码 241-259出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911509359486
关键词
electrospinning; PLGA; MWNTs; hydroxyapatite; biocomposite scaffolds; bone tissue engineering
Biocomposite scaffolds of poly(lactic-co-glycolic acid) (PLGA), multiwalled carbon nanotubes (MWNTs), and hydroxyapatite (HA) nanoparticles were prepared 'by electrospinning' for bone tissue engineering. The structure, surface morphology, and some properties of these PLGA/MWNTs/HA composites were evaluated. Cultured bone marrow-derived mesenchymal stem cells (BMSCs) were seeded on the PLGA/MWNTs/HA scaffolds, and their attachment and proliferation were determined by scanning electron microscopy (SEM) and MTT assay, respectively. The composite scaffolds, a 3D nonwoven fabric construct mimicked the structure of the natural extracellular matrix. The average diameter of the PLGA/MWNTs/HA fibers increased with increasing HA content from 0.5% to 1.5% in the composites. The SEM and MTT results indicated good biocompatibility by the scaffolds, and that the attachment and proliferation of BMSCs were significantly increased in the PLGA/MWNTs/1.0%HA and PLGA/MWNTs/1.5%HA scaffolds compared with the PLGA control. These scaffolds, fabricated by electrospinning, indicate good potential for bone tissue engineering applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据