期刊
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
卷 24, 期 5, 页码 424-443出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0883911509341161
关键词
hyaluronic acid; wound dressing; cross-linking agent; epoxy compound; diabetic ulcer
资金
- National Science Council [NSC 95-2314B-034-001]
- Rotary International Foundation
Several spongy wound dressings composed of various hyaluronic acid (HA) materials were developed: HA aqueous solution with cross-linking agent (epoxy compound (HAWC), without cross-linking agent (HAWOC), and combined bilayer material HAWC and HAWOC (2LHA). The microstructure, sensitivity to hyaluronidase, sensitivity to free radicals, in vitro cytotoxicity, healing potential on full-thickness defect on and diabetic ulcers were evaluated. Scanning electron micrograph views of all HA wound dressings showed an interconnected channel and high porosity structure. HAWOC was degraded rapidly in hyaluronidase and free radical solution. The in vitro cytotoxicity of HAWC was significantly (p<0.05) higher than other HA wound dressings and reduced the released amount of VEGF from human fibroblast. The HAWOC remarkably facilitated the formation of vascularized granulation tissue and provided a HA enrichment wound healing process of either a full-thickness defect or a diabetic ulcer. In contrast, the presence of un-degradable products of HAWC seemed to interfere dermal tissue restoration. Nevertheless, because of the fragile properties, rapid degradation and wound adhesion of HAWOC, the 2LHA should be developed for diabetic ulcer therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据