期刊
NATURE REVIEWS NEUROSCIENCE
卷 16, 期 10, 页码 579-594出版社
NATURE RESEARCH
DOI: 10.1038/nrn4004
关键词
-
资金
- US National Institutes of Health [AA020404, AA006420, AA022249, AA017447, DA023214, DA030359, DA033660]
Brain endocannabinoid (eCB) signalling influences the motivation for natural rewards (such as palatable food, sexual activity and social interaction) and modulates the rewarding effects of addictive drugs. Pathological forms of natural and drug-induced reward are associated with dysregulated eCB signalling that may derive from pre-existing genetic factors or from prolonged drug exposure. Impaired eCB signalling contributes to dysregulated synaptic plasticity, increased stress responsivity, negative emotional states and cravings that propel addiction. Understanding the contributions of eCB disruptions to behavioural and physiological traits provides insight into the eCB influence on addiction vulnerability.
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