期刊
JOURNAL OF BASIC MICROBIOLOGY
卷 48, 期 2, 页码 99-103出版社
WILEY
DOI: 10.1002/jobm.200700292
关键词
Aspergillus; farnesol; conidiation; quorum sensing
类别
Farnesol was the first quorum-sensing regulator to be found in eukaryotic cells. In Candida albicans, a dimorphic fungal human pathogen, farnesol blocks the yeast-to-filamentous growth transition. Here we show that in Aspergillus niger farnesol acts as an inhibitor of conidiation: Colonies grown on media containing farnesol were unable to develop conidia. Although farnesol treated A. niger cultures exhibited a colony morphology resembling the fluffy phenotype of A. nidulans, which is caused by a hyperactive G-protein/cAMP pathway, the intracellular level of cAMP in A. niger mycelia grown in presence of farnesol is greatly diminished. Furthermore, whereas inhibiting adenylyl cyclase led to a farnesol-like effect, the addition of external cAMP inhibited conidiation without causing a fluffy phenotype. This suggests that the mechanisms regulating conidiation in A. niger and A. nidulans are different.
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