相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer's Disease Model
Yaming Wang et al.
CELL (2015)
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
Taylor R. Jay et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2015)
IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior
Paramita Chakrabarty et al.
NEURON (2015)
Emerging Therapeutics for Alzheimer's Disease
Karen Chiang et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 54 (2014)
TREM2 and the neuroimmunology of Alzheimer's disease
Suzanne E. Hickman et al.
BIOCHEMICAL PHARMACOLOGY (2014)
Sublime Microglia: Expanding Roles for the Guardians of the CNS
Michael W. Salter et al.
CELL (2014)
Molecular Links Between Endothelial Dysfunction and Neurodegeneration in Alzheimer's Disease
Epameinondas Lyros et al.
CURRENT ALZHEIMER RESEARCH (2014)
Mild Cognitive Impairment in Patients with Moderate to Severe Chronic Plaque Psoriasis
Paolo Gisondi et al.
DERMATOLOGY (2014)
Differential role of CCR2 in the dynamics of microglia and perivascular macrophages during prion disease
Diego Gomez-Nicola et al.
GLIA (2014)
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Peter J. Murray et al.
IMMUNITY (2014)
Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation
Jia Xue et al.
IMMUNITY (2014)
Interleukin-23 receptor polymorphisms are associated with Alzheimer's disease in Han Chinese
Ying Liu et al.
JOURNAL OF NEUROIMMUNOLOGY (2014)
Body Fluid Cytokine Levels in Mild Cognitive Impairment and Alzheimer's Disease: a Comparative Overview
Frederic Brosseron et al.
MOLECULAR NEUROBIOLOGY (2014)
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
Jason D. Ulrich et al.
MOLECULAR NEURODEGENERATION (2014)
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice
Saul A. Villeda et al.
NATURE MEDICINE (2014)
Microglial priming in neurodegenerative disease
V. Hugh Perry et al.
NATURE REVIEWS NEUROLOGY (2014)
Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
Marco Prinz et al.
NATURE REVIEWS NEUROSCIENCE (2014)
Reactive Gliosis and the Multicellular Response to CNS Damage and Disease
Joshua E. Burda et al.
NEURON (2014)
Soluble Aβ Oligomers Are Rapidly Sequestered from Brain ISF In Vivo and Bind GM1 Ganglioside on Cellular Membranes
Soyon Hong et al.
NEURON (2014)
Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes
Towfique Raj et al.
SCIENCE (2014)
Parallel Discovery of Alzheimer's Therapeutics
Andrew W. Lo et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
Gernot Kleinberger et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Innate immune activation in neurodegenerative disease
Michael T. Heneka et al.
NATURE REVIEWS IMMUNOLOGY (2014)
Microglia actions in Alzheimer’s disease
Stefan Prokop et al.
ACTA NEUROPATHOLOGICA (2013)
Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease-Like Pathology in Mice
Rodrigo Medeiros et al.
AMERICAN JOURNAL OF PATHOLOGY (2013)
Effect of Complement CR1 on Brain Amyloid Burden During Aging and Its Modification by APOE Genotype
Madhav Thambisetty et al.
BIOLOGICAL PSYCHIATRY (2013)
Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice
Sandra Sivilia et al.
BMC NEUROSCIENCE (2013)
SnapShot: Pathobiology of Alzheimer's Disease
Dennis J. Selkoe
CELL (2013)
Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor
Christopher N. Parkhurst et al.
CELL (2013)
Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer's Disease
Bin Zhang et al.
CELL (2013)
CHF5074 Reduces Biomarkers of Neuroinflammation in Patients with Mild Cognitive Impairment: A 12-Week, Double-Blind, Placebo-Controlled Study
Joel Ross et al.
CURRENT ALZHEIMER RESEARCH (2013)
Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony
Rodrigo Medeiros et al.
EXPERIMENTAL NEUROLOGY (2013)
Microglia and neurodegeneration: The role of systemic inflammation
Colm Cunningham
GLIA (2013)
Transcription factors and CD4 T cells seeking identity: masters, minions, setters and spikers
Golnaz Vahedi et al.
IMMUNOLOGY (2013)
Regulators of chromatin state and transcription in CD4 T-cell polarization
Steven Z. Josefowicz
IMMUNOLOGY (2013)
Anti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer's disease mice model
Peng Jin et al.
JOURNAL OF NEUROINFLAMMATION (2013)
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
Michael T. Heneka et al.
NATURE (2013)
CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
Frederick J. Sheedy et al.
NATURE IMMUNOLOGY (2013)
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology
Elizabeth M. Bradshaw et al.
NATURE NEUROSCIENCE (2013)
The microglial sensome revealed by direct RNA sequencing
Suzanne E. Hickman et al.
NATURE NEUROSCIENCE (2013)
Deciphering the mechanism underlying late-onset Alzheimer disease
Dimitrije Krstic et al.
NATURE REVIEWS NEUROLOGY (2013)
Alzheimer disease therapy-moving from amyloid-β to tau
Ezio Giacobini et al.
NATURE REVIEWS NEUROLOGY (2013)
Neuroinflammatory phenotype in early Alzheimer's disease
Tiffany L. Sudduth et al.
NEUROBIOLOGY OF AGING (2013)
Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy
Kevin R. Nash et al.
NEUROBIOLOGY OF AGING (2013)
Microglia as Dynamic and Essential Components of the Amyloid Hypothesis
Sam Gandy et al.
NEURON (2013)
Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer's Disease
Kurt M. Lucin et al.
NEURON (2013)
Alzheimer's Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta
Ana Griciuc et al.
NEURON (2013)
Neuroinflammatory Cytokine Signaling and Alzheimer's Disease
W. Sue T. Griffin
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Variant of TREM2 Associated with the Risk of Alzheimer's Disease
Thorlakur Jonsson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
TREM2 Variants in Alzheimer's Disease
Rita Guerreiro et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Functional Impairment of Microglia Coincides with Beta-Amyloid Deposition in Mice with Alzheimer-Like Pathology
Grietje Krabbe et al.
PLOS ONE (2013)
Comment on ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Nicholas F. Fitz et al.
SCIENCE (2013)
Comment on ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Ina Tesseur et al.
SCIENCE (2013)
Comment on ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Karthikeyan Veeraraghavalu et al.
SCIENCE (2013)
Comment on ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Ashleigh R. Price et al.
SCIENCE (2013)
Scara1 deficiency impairs clearance of soluble amyloid-beta by mononuclear phagocytes and accelerates Alzheimer's-like disease progression
Dan Frenkel et al.
NATURE COMMUNICATIONS (2013)
A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model
Isaac M. Chiu et al.
CELL REPORTS (2013)
The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease
Alexander H. Stephan et al.
ANNUAL REVIEW OF NEUROSCIENCE, VOL 35 (2012)
AAV serotype 2/1-mediated gene delivery of anti-inflammatory interleukin-10 enhances neurogenesis and cognitive function in APP+PS1 mice
T. Kiyota et al.
GENE THERAPY (2012)
Obesity is associated with hypothalamic injury in rodents and humans
Joshua P. Thaler et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Defining GM-CSF- and Macrophage-CSF Dependent Macrophage Responses by In Vitro Models
Derek C. Lacey et al.
JOURNAL OF IMMUNOLOGY (2012)
Systemic immune challenges trigger and drive Alzheimer-like neuropathology in mice
Dimitrije Krstic et al.
JOURNAL OF NEUROINFLAMMATION (2012)
Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study
David H. Cribbs et al.
JOURNAL OF NEUROINFLAMMATION (2012)
PPARγ/RXRα-Induced and CD36-Mediated Microglial Amyloid-β Phagocytosis Results in Cognitive Improvement in Amyloid Precursor Protein/Presenilin 1 Mice
Mitsugu Yamanaka et al.
JOURNAL OF NEUROSCIENCE (2012)
Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease
Jennifer L. Furman et al.
JOURNAL OF NEUROSCIENCE (2012)
The Complex PrPc-Fyn Couples Human Oligomeric Aβ with Pathological Tau Changes in Alzheimer's Disease
Megan Larson et al.
JOURNAL OF NEUROSCIENCE (2012)
Hippocampal expression of murine IL-4 results in exacerbation of amyloid deposition
Paramita Chakrabarty et al.
MOLECULAR NEURODEGENERATION (2012)
A mutation in APP protects against Alzheimer's disease and age-related cognitive decline
Thorlakur Jonsson et al.
NATURE (2012)
Inhibition of IL-12/IL-23 signaling reduces Alzheimer's disease-like pathology and cognitive decline
Johannes vom Berg et al.
NATURE MEDICINE (2012)
Animal models of multiple sclerosis: the good, the bad and the bottom line
Richard M. Ransohoff
NATURE NEUROSCIENCE (2012)
Mast cells: an expanding pathophysiological role from allergy to other disorders
Preet Anand et al.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2012)
In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer's disease through GSK3β and secretases
Juan Ignacio Diaz-Hernandez et al.
NEUROBIOLOGY OF AGING (2012)
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
William T. Hu et al.
NEUROLOGY (2012)
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Dorothy P. Schafer et al.
NEURON (2012)
Functions of microglia in the central nervous system – beyond the immune response
Hiroaki Wake et al.
Neuron Glia Biology (2012)
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Paige E. Cramer et al.
SCIENCE (2012)
Inflammation in Alzheimer Disease-A Brief Review of the Basic Science and Clinical Literature
Tony Wyss-Coray et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Neurotoxicity of Amyloid β-Protein: Synaptic and Network Dysfunction
Lennart Mucke et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Neurovascular Dysfunction and Faulty Amyloid β-Peptide Clearance in Alzheimer Disease
Abhay P. Sagare et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Proteolytic Degradation of Amyloid β-Protein
Takaomi Saido et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Animal Models of Alzheimer Disease
Frank M. LaFerla et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Trafficking and Proteolytic Processing of APP
Christian Haass et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
Clearance of amyloid-β peptides by microglia and macrophages: the issue of what, when and where
Aaron Y. Lai et al.
FUTURE NEUROLOGY (2012)
Extended results of the Alzheimer's disease anti-inflammatory prevention trial
John C. Breitner et al.
ALZHEIMERS & DEMENTIA (2011)
Multiple Cellular and Molecular Mechanisms Are Involved in Human Aβ Clearance by Transplanted Adult Astrocytes
Rea Pihlaja et al.
GLIA (2011)
Helper T-cell differentiation and plasticity: insights from epigenetics
Kiyoshi Hirahara et al.
IMMUNOLOGY (2011)
Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice
Stephanos Kyrkanides et al.
JOURNAL OF NEUROINFLAMMATION (2011)
Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease
Paula Grammas
JOURNAL OF NEUROINFLAMMATION (2011)
Robust Amyloid Clearance in a Mouse Model of Alzheimer's Disease Provides Novel Insights into the Mechanism of Amyloid-β Immunotherapy
Allan Wang et al.
JOURNAL OF NEUROSCIENCE (2011)
Distinct and Non-Redundant Roles of Microglia and Myeloid Subsets in Mouse Models of Alzheimer's Disease
Alexander Mildner et al.
JOURNAL OF NEUROSCIENCE (2011)
Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-α Expression for Microglial Aβ Phagocytosis
Dick Terwel et al.
JOURNAL OF NEUROSCIENCE (2011)
Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?
Markel Olabarria et al.
MOLECULAR NEURODEGENERATION (2011)
Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
Paramita Chakrabarty et al.
MOLECULAR NEURODEGENERATION (2011)
The ageing systemic milieu negatively regulates neurogenesis and cognitive function
Saul A. Villeda et al.
NATURE (2011)
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Stephen Sawcer et al.
NATURE (2011)
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
Adam C. Naj et al.
NATURE GENETICS (2011)
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
Paul Hollingworth et al.
NATURE GENETICS (2011)
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
Marco Prinz et al.
NATURE NEUROSCIENCE (2011)
Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Rosa C. Paolicelli et al.
SCIENCE (2011)
Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial
Francois Piette et al.
ALZHEIMERS RESEARCH & THERAPY (2011)
Transcriptional regulation of macrophage polarization: enabling diversity with identity
Toby Lawrence et al.
NATURE REVIEWS IMMUNOLOGY (2011)
Astrocytes: biology and pathology
Michael V. Sofroniew et al.
ACTA NEUROPATHOLOGICA (2010)
Focal demyelination in Alzheimer's disease and transgenic mouse models
Stanislaw Mitew et al.
ACTA NEUROPATHOLOGICA (2010)
Contribution of systemic inflammation to chronic neurodegeneration
V. Hugh Perry
ACTA NEUROPATHOLOGICA (2010)
CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models
Sungho Lee et al.
AMERICAN JOURNAL OF PATHOLOGY (2010)
A Meta-Analysis of Cytokines in Alzheimer's Disease
Walter Swardfager et al.
BIOLOGICAL PSYCHIATRY (2010)
Cause-specific mortality in patients with severe psoriasis: a population-based cohort study in the UK
K. Abuabara et al.
BRITISH JOURNAL OF DERMATOLOGY (2010)
Massive gliosis induced by interleukin-6 suppresses Aβ deposition in vivo: evidence against inflammation as a driving force for amyloid deposition
Paramita Chakrabarty et al.
FASEB JOURNAL (2010)
Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis
Theodore J. Iwashyna et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2010)
The role of microglia in amyloid clearance from the AD brain
C. Y. Daniel Lee et al.
JOURNAL OF NEURAL TRANSMISSION (2010)
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
Cameron R. Stewart et al.
NATURE IMMUNOLOGY (2010)
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease
Martin Fuhrmann et al.
NATURE NEUROSCIENCE (2010)
Alzheimer's disease: strategies for disease modification
Martin Citron
NATURE REVIEWS DRUG DISCOVERY (2010)
Systemic inflammatory cells fight off neurodegenerative disease
Michal Schwartz et al.
NATURE REVIEWS NEUROLOGY (2010)
Microglia in neurodegenerative disease
V. Hugh Perry et al.
NATURE REVIEWS NEUROLOGY (2010)
MECHANISMS OF DISEASE Alzheimer's Disease
Henry W. Querfurth et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Aβ deposition in an Alzheimer mouse model with diabetes
Shuko Takeda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Decreased Clearance of CNS β-Amyloid in Alzheimer's Disease
Kwasi G. Mawuenyega et al.
SCIENCE (2010)
Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease
Colm Cunningham et al.
BIOLOGICAL PSYCHIATRY (2009)
CHF5074, a novel γ-secretase modulator, attenuates brain β-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease
B. P. Imbimbo et al.
BRITISH JOURNAL OF PHARMACOLOGY (2009)
Quantitative and Mechanistic Studies of A beta Immunotherapy
Todd E. Golde et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2009)
Decreased expression of CD200 and CD200 receptor in Alzheimer's disease: A potential mechanism leading to chronic inflammation
Douglas G. Walker et al.
EXPERIMENTAL NEUROLOGY (2009)
A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
Christine L. Hsieh et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β
Alessandro Michelucci et al.
JOURNAL OF NEUROIMMUNOLOGY (2009)
CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar Aβ-Stimulated Microglial Activation
Erin G. Reed-Geaghan et al.
JOURNAL OF NEUROSCIENCE (2009)
An Immunofluorescence Method for Postembedded Tissue in the Acrylic Resin Technovit 9100 New® Using Fluorescein Isothiocyanate Secondary Detection
Sim K. Singhrao et al.
MICROSCOPY RESEARCH AND TECHNIQUE (2009)
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
Jean-Charles Lambert et al.
NATURE GENETICS (2009)
Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia
Stefan A. Grathwohl et al.
NATURE NEUROSCIENCE (2009)
Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway
Vanja Vukic et al.
NEUROBIOLOGY OF DISEASE (2009)
Systemic inflammation and disease progression in Alzheimer disease
C. Holmes et al.
NEUROLOGY (2009)
Selective targeting of perivascular macrophages for clearance of β-amyloid in cerebral amyloid angiopathy
Cheryl A. Hawkes et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Decrease in the Numbers of Dendritic Cells and CD4+ T Cells in Cerebral Perivascular Spaces Due to Natalizumab
Maria del Pilar Martin et al.
ARCHIVES OF NEUROLOGY (2008)
TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice
Stefanie Frank et al.
GLIA (2008)
Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease
Jing-Ji Jin et al.
JOURNAL OF NEUROINFLAMMATION (2008)
Rapid cognitive improvement in Alzheimer's disease following perispinal etanercept administration
Edward L. Tobinick et al.
JOURNAL OF NEUROINFLAMMATION (2008)
Complement C3 deficiency leads to accelerated amyloid β plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice
Marcel Maier et al.
JOURNAL OF NEUROSCIENCE (2008)
Rapid Microglial Response Around Amyloid Pathology after Systemic Anti-Aβ Antibody Administration in PDAPP Mice
Jessica Koenigsknecht-Talboo et al.
JOURNAL OF NEUROSCIENCE (2008)
Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice
Suzanne E. Hickman et al.
JOURNAL OF NEUROSCIENCE (2008)
Long-term effects of Aβ42 immunisation in Alzheimer's disease:: follow-up of a randomised, placebo-controlled phase I trial
Clive Holmes et al.
LANCET (2008)
The NALP3 inflammasome is involved in the innate immune response to amyloid-β
Annett Halle et al.
NATURE IMMUNOLOGY (2008)
Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimer's disease
Jae K. Ryu et al.
NEUROREPORT (2008)
A limited role for microglia in antibody mediated plaque clearance in APP mice
Monica Garcia-Alloza et al.
NEUROBIOLOGY OF DISEASE (2007)
Inside, outside, upside down: damage-associated molecular-pattern molecules (DAMPs) and redox
Anna Rubartelli et al.
TRENDS IN IMMUNOLOGY (2007)
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
Joseph El Khoury et al.
NATURE MEDICINE (2007)
Soluble protein oligomers in neurodegeneration:: lessons from the Alzheimer's amyloid β-peptide
Christian Haass et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
The effects of aging, injury and disease on microglial function: a case for cellular senescence
Kelly R. Miller et al.
NEURON GLIA BIOLOGY (2007)
Peripheral inflammatory Cytokines as biomarkers in Alzheimer's disease and mild cognitive impairment
Rita Joao Guerreiro et al.
NEURODEGENERATIVE DISEASES (2007)
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
AR Simard et al.
NEURON (2006)
Locus Ceruleus degeneration promotes Alzheimer pathogenesis in amyloid precursor protein 23 transgenic mice
MT Heneka et al.
JOURNAL OF NEUROSCIENCE (2006)
Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice
AK Stalder et al.
JOURNAL OF NEUROSCIENCE (2005)
Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures
M Lotz et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease
Nikunj S. Patel et al.
JOURNAL OF NEUROINFLAMMATION (2005)
Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice
Michael T. Heneka et al.
JOURNAL OF NEUROINFLAMMATION (2005)
Constitutive repressor activity of CD33 on human monocytes requires sialic acid recognition and phosphoinositide 3-kinase-mediated intracellular signaling
F Lajaunias et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2005)
Tumor necrosis factor death receptor signaling cascade is required for amyloid-β protein-induced neuron death
R Li et al.
JOURNAL OF NEUROSCIENCE (2004)
Microglial activation facilitates Aβ plaque removal following intracranial anti-Aβ antibody administration
DM Wilcock et al.
NEUROBIOLOGY OF DISEASE (2004)
Absence of C1q leads to less neuropathology in transgenic mouse models of Alzheimer's disease
MI Fonseca et al.
JOURNAL OF NEUROSCIENCE (2004)
Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition
DM Wilcock et al.
JOURNAL OF NEUROSCIENCE (2004)
Microglia and Alzheimer's disease pathogenesis
WJ Streit
JOURNAL OF NEUROSCIENCE RESEARCH (2004)
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
M Koistinaho et al.
NATURE MEDICINE (2004)
Microglial phagocytosis of fibrillar β-amyloid through a β1 integrin-dependent mechanism
J Koenigsknecht et al.
JOURNAL OF NEUROSCIENCE (2004)
Amyloid β-peptide interactions with neuronal and glial cell plasma membrane:: Binding sites and implications for Alzheimer's disease
Y Verdier et al.
JOURNAL OF PEPTIDE SCIENCE (2004)
Intrathecal inflammation precedes development of Alzheimer's disease
E Tarkowski et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2003)
CD36 mediates the innate host response to β-amyloid
JB El Khoury et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2003)
Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression - A randomized controlled trial
PS Aisen et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)
Expression of complement messenger RNAs and proteins by human oligodendroglial cells
M Hosokawa et al.
GLIA (2003)
Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains
RG Nagele et al.
BRAIN RESEARCH (2003)
Adult mouse astrocytes degrade amyloid-β in vitro and in situ
T Wyss-Coray et al.
NATURE MEDICINE (2003)
Role of CD40 ligand in amyloidosis in transgenic Alzheimer's mice
J Tan et al.
NATURE NEUROSCIENCE (2002)
Neuroinflammation in Alzheimer's disease and prion disease
P Eikelenboom et al.
GLIA (2002)
The potential of anti-inflammatory drugs for the treatment of Alzheimer's disease
PS Aisen
LANCET NEUROLOGY (2002)
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice
T Wyss-Coray et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Up-regulation of FPR2, a chemotactic receptor for amyloid β 1-42 (Aβ42), in murine microglial cells by TNFα
YH Cui et al.
NEUROBIOLOGY OF DISEASE (2002)
Medicine - The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
J Hardy et al.
SCIENCE (2002)
Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
BA in 't Veld et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice
T Wyss-Coray et al.
NATURE MEDICINE (2001)
Identification of a CD20-, FcεRIβ-, and HTm4-related gene family:: Sixteen new MS4A family members expressed in human and mouse
YH Liang et al.
GENOMICS (2001)
A beta-Induce inflammatory processes in microglia cells of APP23 transgenic mice
KD Bornemann et al.
AMERICAN JOURNAL OF PATHOLOGY (2001)
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
F Bard et al.
NATURE MEDICINE (2000)
M-1/M-2 macrophages and the Th1/Th2 paradigm
CD Mills et al.
JOURNAL OF IMMUNOLOGY (2000)
Inflammation and Alzheimer's disease
H Akiyama et al.
NEUROBIOLOGY OF AGING (2000)