期刊
NATURE REVIEWS NEUROSCIENCE
卷 16, 期 8, 页码 469-486出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn3978
关键词
-
资金
- Dennis Weatherstone Predoctoral Fellowship from Autism Speaks [7825]
- ARCS (Achievement Rewards for College Scientists) Foundation
- University of California Office of the President
- National Institute of Neurological Disorders and Stroke (NINDS) [R01-NS060125-05]
- National Institute of Mental Health (NIMH) [P50-MH106438-01]
- Simons Foundation (SFARI) [321998]
- University of California Davis Research Investments in Science and Engineering Program
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH106438, F32MH010643] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS060125] Funding Source: NIH RePORTER
Increasing evidence points to a central role for immune dysregulation in autism spectrum disorder (ASD). Several ASD risk genes encode components of the immune system and many maternal immune system-related risk factors - including autoimmunity, infection and fetal reactive antibodies - are associated with ASD. In addition, there is evidence of ongoing immune dysregulation in individuals with ASD and in animal models of this disorder. Recently, several molecular signalling pathways - including pathways downstream of cytokines, the receptor MET, major histocompatibility complex class I molecules, microglia and complement factors - have been identified that link immune activation to ASD phenotypes. Together, these findings indicate that the immune system is a point of convergence for multiple ASD-related genetic and environmental risk factors.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据