期刊
NATURE REVIEWS NEUROLOGY
卷 11, 期 2, 页码 111-122出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrneurol.2014.264
关键词
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资金
- MD Medical Student Research Fund in Genetics (Yale University School of Medicine)
- Student Scholarship in Cerebrovascular Disease and Stroke (American Heart Association Stroke Council)
- National Institute of Neurological Disorders and Stroke (NINDS) [K12-NS049453]
- Department of Veterans Affairs (Baltimore) [BX001629]
- NINDS [NS060801, NS061808]
- National Heart, Lung and Blood Institute [HL082517]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL082517] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS061808, K12NS049453] Funding Source: NIH RePORTER
Perihaematomal oedema (PHO) is an important pathophysiological marker of secondary injury in intracerebral haemorrhage (ICH). In this Review, we describe a novel method to conceptualize PHO formation within the framework of Starling's principle of movement of fluid across a capillary wall. We consider progression of PHO through three stages, characterized by ionic oedema (stage 1) and progressive vasogenic oedema (stages 2 and 3). In this context, possible modifiers of PHO volume and their value in identifying patients who would benefit from therapies that target secondary injury are discussed; the practicalities of using neuroimaging to measure PHO volume are also considered. We examine whether PHO can be used as a predictor of neurological outcome following ICH, and we provide an overview of emerging therapies. Our discussion emphasizes that PHO has clinical relevance both as a therapeutic target, owing to its augmentation of the mass effect of a haemorrhage, and as a surrogate marker for novel interventions that target secondary injury.
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