期刊
NATURE REVIEWS NEUROLOGY
卷 11, 期 9, 页码 524-535出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrneurol.2015.144
关键词
-
资金
- National Basic Research Program of China [2013CB966900]
- National Natural Science Foundation of China [81230,028]
- NIH [R01AI083294, R01NS34179, R01NS081179]
- American Heart Association [14GRNT18970031]
- Foundation Leducq
- National Key Clinical Speciality Construction Project of China
Approaches for the effective management of acute stroke are sparse, and many measures for brain protection fail. However, our ability to modulate the immune system and modify the progression of multiple sclerosis is increasing. As a result, immune interventions are currently being explored as therapeutic interventions in acute stroke. In this Review, we compare the immunological features of acute stroke with those of multiple sclerosis, identify unique immunological features of stroke, and consider the evidence for immune interventions. In patients with acute stroke, microglial activation and cell death products trigger an inflammatory cascade that damages vessels and the parenchyma within minutes to hours of the ischaemia or haemorrhage. Immune interventions that restrict brain inflammation, vascular permeability and tissue oedema must be administered rapidly to reduce acute immune-mediated destruction and to avoid subsequent immunosuppression. Preliminary results suggest that the use of drugs that modify disease in multiple sclerosis might accomplish these goals in ischaemic and haemorrhagic stroke. Further elucidation of the immune mechanisms involved in stroke is likely to lead to successful immune interventions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据