期刊
JOURNAL OF BACTERIOLOGY
卷 193, 期 23, 页码 6770-6780出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.05929-11
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资金
- NIH [R01A1003256]
- MRC
- United Kingdom BBSRC
- Cancer Research UK [6934] Funding Source: researchfish
Pseudomonas aeruginosa is an opportunistic pathogen capable of group behaviors, including biofilm formation and swarming motility. These group behaviors are regulated by both the intracellular signaling molecule c-di-GMP and acylhomoserine lactone quorum-sensing systems. Here, we show that the Pseudomonas quinolone signal (PQS) system also contributes to the regulation of swarming motility. Specifically, our data indicate that 2-heptyl-4-quinolone (HHQ), a precursor of PQS, likely induces the production of the phenazine-1-carboxylic acid (PCA), which in turn acts via an as-yet-unknown downstream mechanism to repress swarming motility. We show that this HHQ- and PCA-dependent swarming repression is apparently independent of changes in global levels of c-di-GMP, suggesting complex regulation of this group behavior.
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