期刊
JOURNAL OF BACTERIOLOGY
卷 193, 期 4, 页码 1018-1020出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01158-10
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资金
- National Institutes of Health [AI49003, AI37256, AI30071, GM083722, RR03037]
- Lyme Disease Association
- Tami Fund
Borrelia burgdorferi is a causative agent of Lyme disease in North America and Eurasia. The first complete genome sequence of B. burgdorferi strain 31, available for more than a decade, has assisted research on the pathogenesis of Lyme disease. Because a single genome sequence is not sufficient to understand the relationship between genotypic and geographic variation and disease phenotype, we determined the whole-genome sequences of 13 additional B. burgdorferi isolates that span the range of natural variation. These sequences should allow improved understanding of pathogenesis and provide a foundation for novel detection, diagnosis, and prevention strategies.
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