期刊
JOURNAL OF BACTERIOLOGY
卷 192, 期 2, 页码 604-607出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01239-09
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- NIH [AI49561]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI049561] Funding Source: NIH RePORTER
The MgtA protein from Salmonella enterica serovar Typhimurium mediates Mg2+ uptake from the periplasm into the cytoplasm. Here we report that the PhoP/PhoQ two-component regulatory system, which responds to periplasmic Mg2+, governs mgtA transcription initiation at all investigated Mg2+ concentrations and that the Mg2+-sensing 5' leader region of the mgtA gene controls transcription elongation into the mgtA coding region when Salmonella is grown in media with < 50 mu M Mg2+. Overexpression of the Mg2+ transporter CorA, which is believed to increase cytoplasmic Mg2+ levels, decreased mgtA transcription in a manner dependent on a functional mgtA 5' leader.
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