期刊
JOURNAL OF BACTERIOLOGY
卷 191, 期 9, 页码 3189-3194出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01771-08
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A gene unique to Streptococcus pyogenes, called vfr, that negatively regulates speB, an important extracellular proteinase, has been identified. Disruption of vfr markedly increased SpeB production in a clinical strain of S. pyogenes and relieved its growth phase dependency. These findings may provide important insights into the pathogenesis of invasive S. pyogenes infections.
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