期刊
JOURNAL OF BACTERIOLOGY
卷 191, 期 10, 页码 3407-3410出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.01722-08
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资金
- National Institutes of Health [GM29408]
Cobalamin-independent methionine synthase (MetE) catalyzes the final step in Escherichia coli methionine biosynthesis but is inactivated under oxidative conditions, triggering a methionine deficiency. This study demonstrates that the mutation of MetE cysteine 645 to alanine completely eliminates the methionine auxotrophy imposed by diamide treatment, suggesting that modulation of MetE activity via cysteine 645 oxidation has significant physiological consequences for oxidatively stressed cells.
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