期刊
JOURNAL OF BACTERIOLOGY
卷 191, 期 14, 页码 4487-4491出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00056-09
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资金
- NIH
- National Cancer Institute
- Center for Cancer Research,
- 6th European Community Framework Program
- Danish National Research Foundation
- OTKA [PD75496]
- Hungarian Academy of Sciences
Many transcription factors repress transcription of their own genes. Negative autoregulation has been shown to reduce cell-cell variation in regulatory protein levels and speed up the response time in gene networks. In this work we examined transcription regulation of the galS gene and the function of its product, the GalS protein. We observed a unique operator preference of the GalS protein characterized by dominant negative autoregulation. We show that this pattern of regulation limits the repression level of the target genes in steady states. We suggest that transcription factors with dominant negative autoregulation are designed for regulating gene expression during environmental transitions.
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