期刊
JOURNAL OF BACTERIOLOGY
卷 190, 期 15, 页码 5522-5525出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00312-08
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- NIAID NIH HHS [R01 AI055860, AI055860] Funding Source: Medline
The ResDE two-component system regulates the synthesis of several components of the aerobic and anaerobic respiratory pathways in bacilli. The ResD response regulator transcription factor has been implicated in the regulation of virulence factors in a number of gram-positive species, including Bacillus anthracis. The precise deletions of resD and resE in B. anthracis that retained the classical respiratory phenotypes did not affect the expression of the gene for the protective antigen of the anthrax toxin, pagA, or that of the toxin regulator, atxA. The results indicate that the loss of ResDE-controlled respiratory capacity does not affect the synthesis of anthrax toxin.
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