期刊
JOURNAL OF BACTERIOLOGY
卷 190, 期 15, 页码 5526-5530出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00558-08
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- NIAID NIH HHS [AI08619, R01 AI008619] Funding Source: Medline
- NIGMS NIH HHS [R01 GM054158, GM54158] Funding Source: Medline
The Streptomyces coelicolor absB gene encodes an RNase III family endoribonuclease and is normally essential for antibiotic biosynthesis. Here we report that AbsB controls its own expression by sequentially and site specifically cleaving stem-loop segments of its polycistronic transcript. Our results demonstrate a ribonucleolytic regulatory role for AbsB in vivo.
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