期刊
JOURNAL OF BACTERIOLOGY
卷 190, 期 20, 页码 6909-6912出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00451-08
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资金
- Australian National Health
- Medical Research Council [455914]
- Australian Research Council [DP0666852]
- University of Queensland
- Australian Research Council [DP0666852] Funding Source: Australian Research Council
The periplasmic multicopper oxidase (CueO) is involved in copper homeostasis and protection against oxidative stress. Here, we show that the deletion of cueO in uropathogenic Escherichia coli increases its colonization of the urinary tract despite its increased sensitivity to hydrogen peroxide. The cueO deletion mutant accumulated iron with increased efficiency compared to its parent strain; this may account for its advantage in the iron-limited environment of the urinary tract.
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