期刊
JOURNAL OF BACTERIOLOGY
卷 191, 期 1, 页码 210-219出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00797-08
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资金
- NIH [R21-AI068662, 5KO8-EY13977]
- Richter Memorial Fund of Dartmouth College
- NATIONAL EYE INSTITUTE [K08EY013977] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R21AI068662] Funding Source: NIH RePORTER
Bacteriophage infection has profound effects on bacterial biology. Clustered regular interspaced short palindromic repeats (CRISPRs) and cas (CRISPR- associated) genes are found in most archaea and many bacteria and have been reported to play a role in resistance to bacteriophage infection. We observed that lysogenic infection of Pseudomonas aeruginosa PA14 with bacteriophage DMS3 inhibits biofilm formation and swarming motility, both important bacterial group behaviors. This inhibition requires the CRISPR region in the host. Mutation or deletion of five of the six cas genes and one of the two CRISPRs in this region restored biofilm formation and swarming to DMS3 lysogenized strains. Our observations suggest a role for CRISPR regions in modifying the effects of lysogeny on P. aeruginosa.
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