期刊
JOURNAL OF BACTERIOLOGY
卷 190, 期 18, 页码 6271-6275出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.00860-08
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资金
- National Institutes of Health (NIH) [GM-35394]
- Southeast Regional Center of Excellence for Biodefense and Emerging Infections SERCEB
- SERCEB
- National Institute of Allergy and Infectious Diseases NIAID
- Oak Ridge Institute for Science and Education (ORISE)
- Oak Ridge Associated Universities [DE-AC05-06OR23100]
In Bacillus anthracis, the novel type III pantothenate kinase (PanK(Ba); encoded by coaX) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanK(Ba) is an essential enzyme, thus contributing to its validation as a new antimicrobial target.
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