期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 16, 期 8, 页码 499-U78出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm4029
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资金
- Association Francaise contre les Myopathies -Telethon (AFM)
- Institut National du Cancer (INCa)
- Agence Nationale de la Recherche (ANR), Fondation Association pour la Recherche sur le Cancer (ARC)
- French government through its 'Investments for the Future' programme [ANR-11-LABEX-0071, ANR-11-IDEX-0005-01]
- Groupement des Entreprises Francaises pour la Lutte contre le Cancer (GEFLUC)
- CNRS and Universite Paris Diderot
- FRM fellowship
- EMBO fellowship
- grant INCa
- Ministere de la Recherche
- Fondation ARC Ph.D. fellowship
- Transition postdoctoral 'Who am I?' fellowship
The methylation of histone Lys residues by Lys methyltransferases (KMTs) regulates chromatin organization and either activates or represses gene expression, depending on the residue that is targeted. KMTs are emerging as key components in several cellular processes, and their deregulation is often associated with pathogenesis. Here, we review the current knowledge on the main KMTs that are associated with gene silencing: namely, those responsible for methylating histone H3 Lys 9 (H3K9), H3K27 and H4K20. We discuss their biochemical properties and the various mechanisms by which they are targeted to the chromatin and regulate gene expression, as well as new data on the interplay between them and other chromatin modifiers.
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