期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 16, 期 10, 页码 593-610出版社
NATURE PORTFOLIO
DOI: 10.1038/nrm4048
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资金
- US National Science Foundation GRFP
- US National Institutes of Health (NIH) [F31 AG043232]
- NIH [DP1 AG044848, P01 AG036695]
- Glenn Laboratories for the Biology of Aging
- [K99 AG049934]
Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-based epigenetic changes that occur during ageing, the role of chromatin modifiers in modulating lifespan and the importance of epigenetic signatures as biomarkers of ageing. We also discuss how epigenome remodelling by environmental stimuli affects several aspects of transcription and genomic stability, with important consequences for longevity, and outline epigenetic differences between the 'mortal soma' and the 'immortal germ line'. Finally, we discuss the inheritance of characteristics of ageing and potential chromatin-based strategies to delay or reverse hallmarks of ageing or age-related diseases.
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