期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 16, 期 8, 页码 461-472出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm4024
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资金
- US National Institutes of Health [CA126792, CA188404]
- Department of Defense Breast Cancer Research Program [W81XWH-11-1-0130]
- Samuel Waxman Cancer Research Foundation
- NATIONAL CANCER INSTITUTE [R01CA126792, R01CA188404] Funding Source: NIH RePORTER
Autophagy is a conserved catabolic process that degrades cytoplasmic constituents and organelles in the lysosome. Starvation-induced protein degradation is a salient feature of autophagy but recent progress has illuminated how autophagy, during both starvation and nutrient-replete conditions, can mobilize diverse cellular energy and nutrient stores such as lipids, carbohydrates and iron. Processes such as lipophagy, glycophagy and ferritinophagy enable cells to salvage key metabolites to sustain and facilitate core anabolic functions. Here, we discuss the established and emerging roles of autophagy in fuelling biosynthetic capacity and in promoting metabolic and nutrient homeostasis.
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