期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 16, 期 1, 页码 18-29出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3920
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- US National Institutes of Health [CA096865, GM71862]
- Skaggs Institute for Chemical Biology
- NATIONAL CANCER INSTITUTE [R01CA096865] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM071862] Funding Source: NIH RePORTER
Intrinsically disordered proteins (IDPs) are important components of the cellular signalling machinery, allowing the same polypeptide to undertake different interactions with different consequences. IDPs are subject to combinatorial post-translational modifications and alternative splicing, adding complexity to regulatory networks and providing a mechanism for tissue-specific signalling. These proteins participate in the assembly of signalling complexes and in the dynamic self-assembly of membrane-less nuclear and cytoplasmic organelles. Experimental, computational and bioinformatic analyses combine to identify and characterize disordered regions of proteins, leading to a greater appreciation of their widespread roles in biological processes.
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