期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 16, 期 6, 页码 360-374出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm4002
关键词
-
类别
资金
- European Research Council [233339]
- ARC
- Ligue Nationale Contre le Cancer (LNCC)
- European Research Council (ERC) [233339] Funding Source: European Research Council (ERC)
DNA replication begins with the assembly of pre-replication complexes (pre-RCs) at thousands of DNA replication origins during the G1 phase of the cell cycle. At the G1-S-phase transition, pre-RCs are converted into pre-initiation complexes, in which the replicative helicase is activated, leading to DNA unwinding and initiation of DNA synthesis. However, only a subset of origins are activated during any S phase. Recent insights into the mechanisms underlying this choice reveal how flexibility in origin usage and temporal activation are linked to chromosome structure and organization, cell growth and differentiation, and replication stress.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据