期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 16, 期 5, 页码 269-280出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm3970
关键词
-
类别
资金
- Wellcome Trust [097945, 073980] Funding Source: Medline
The proteome is a dynamic system in which each protein has interconnected properties-dimensions-that together contribute to the phenotype of a cell. Measuring these properties has proved challenging owing to their diversity and dynamic nature. Advances in mass spectrometry-based proteomics now enable the measurement of multiple properties for thousands of proteins, including their abundance, isoform expression, turnover rate, subcellular localization, post-translational modifications and interactions. Complementing these experimental developments are new data analysis, integration and visualization tools as well as data-sharing resources. Together, these advances in the multidimensional analysis of the proteome are transforming our understanding of various cellular and physiological processes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据