期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 59, 期 4, 页码 2122-2128出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.04579-14
关键词
-
资金
- NIH [HD06153, DE019901]
- Intramural Research Program of the National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health (NIH) [ZIA AI000904-13]
- T32 NIH training grant [T32-AR-052273]
Antibiotic prophylaxis is standard for patients undergoing surgical procedures, yet despite the wide use of antibiotics, breakthrough infections still occur. In the setting of total joint arthroplasty, such infections can be devastating. Recent findings have shown that synovial fluid causes marked staphylococcal aggregation, which can confer antibiotic insensitivity. We therefore asked in this study whether clinical samples of synovial fluid that contain preoperative prophylactic antibiotics can successfully eradicate a bacterial challenge by pertinent bacterial species. This study demonstrates that preoperative prophylaxis with cefazolin results in high antibiotic levels. Furthermore, we show that even with antibiotic concentrations that far exceed the expected bactericidal levels, Staphylococcus aureus bacteria added to the synovial fluid samples are not eradicated and are able to colonize model implant surfaces, i.e., titanium pins. Based on these studies, we suggest that current prophylactic antibiotic choices, despite high penetration into the synovial fluid, may need to be reexamined.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据