期刊
JOURNAL OF AUTOIMMUNITY
卷 39, 期 3, 页码 199-205出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2012.05.008
关键词
Sjogren's syndrome; Autoimmune disease; Polyautoimmunity; Multiple autoimmune syndrome; Smoking; Abortion
类别
资金
- Colciencias [122254531722]
- Universidad del Rosario, Bogota, Colombia
The coexistence of autoimmune diseases (i.e., polyautoimmunity) in Sjogren's syndrome (SS) was investigated in a cross-sectional study involving 410 patients. Logistic regression analysis and the Rogers and Tanimoto index were used to evaluate risk factors and clustering, respectively. There were 134 (32.6%) patients with polyautoimmunity. The most frequent and closer coexistent diseases were autoimmune thyroid disease (21.5%), rheumatoid arthritis (8.3%), systemic lupus erythematosus (7.6%), and inflammatory bowel disease (0.7%) which together constituted a cluster group. There were 35 (8.5%) patients with multiple autoimmune syndrome. Besides disease duration, a history of habitual smoking and spontaneous abortion were found to be risk factors for the developing of polyautoimmunity. This study discloses a high prevalence of polyautoimmunity in SS, its associated risk factors and the grouping pattern of such a condition. These results may serve to define plausible approaches to study the common mechanisms of autoimmune diseases. (C) 2012 Elsevier Ltd. All rights reserved.
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