期刊
NATURE REVIEWS MICROBIOLOGY
卷 13, 期 12, 页码 777-786出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3564
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资金
- UK Biotechnology and Biological Sciences Research Council (BBSRC)
- Cambridge Trusts
- Society for General Microbiology
- Society for Applied Microbiology
- British Society for Plant Pathology
- Marsden Fund
- Royal Society of New Zealand (RSNZ)
- Rutherford Discovery Fellowship (RSNZ)
- University of Otago Research Grant
- Bequest Fund for Research in the Otago School of Medical Sciences
- Bio-Protection Centre of Research Excellence
- Biotechnology and Biological Sciences Research Council [BB/G000298/1, BB/H002677/1] Funding Source: researchfish
- BBSRC [BB/H002677/1, BB/G000298/1] Funding Source: UKRI
Viruses that infect bacteria (bacteriophages; also known as phages) were discovered 100 years ago. Since then, phage research has transformed fundamental and translational biosciences. For example, phages were crucial in establishing the central dogma of molecular biology-information is sequentially passed from DNA to RNA to proteins-and they have been shown to have major roles in ecosystems, and help drive bacterial evolution and virulence. Furthermore, phage research has provided manytechniques and reagents that underpin modern biology-from sequencing and genome engineering to the recent discovery and exploitation of CRISPR-Cas phage resistance systems. In this Timeline, we discuss a century of phage research and its impact on basic and applied biology.
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