期刊
NATURE REVIEWS MICROBIOLOGY
卷 13, 期 3, 页码 160-172出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3402
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资金
- European Union FP7 Network of Excellence EviMalaR
- Monash University
- Australian National Health and Medical Research Council
- Australian Centre for HIV and Hepatitis Virology Research
- Wellcome Trust [098051]
- French Parasitology consortium ParaFrap [ANR-11-LABX0024]
- ERC Advanced grant PlasmoEscape [250320]
- Medical Research Council (Programme Leader - Toxicology Unit)
- European Research Council (ERC) [250320] Funding Source: European Research Council (ERC)
- Biotechnology and Biological Sciences Research Council [1653478] Funding Source: researchfish
- Medical Research Council [G1100712, MC_UP_A600_1110] Funding Source: researchfish
- MRC [MC_UP_A600_1110, G1100712] Funding Source: UKRI
Post-translational modifications play crucial parts in regulating protein function and thereby control several fundamental aspects of eukaryotic biology, including cell signalling, protein trafficking, epigenetic control of gene expression, cell-cell interactions, and cell proliferation and differentiation. In this Review, we discuss protein modifications that have been shown to have a key role in malaria parasite biology and pathogenesis. We focus on phosphorylation, acetylation, methylation and lipidation. We provide an overview of the biological significance of these modifications and discuss prospects and progress in antimalarial drug discovery based on the inhibition of the enzymes that mediate these modifications.
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