期刊
JOURNAL OF AUTOIMMUNITY
卷 33, 期 3-4, 页码 270-274出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2009.03.011
关键词
Systemic lupus erythematosus; Autoantibodies; Ig class switching; Pathogenicity
类别
资金
- NIAID NIH HHS [P01 AI073693, P01 AI073693-01A1] Funding Source: Medline
- NIAMS NIH HHS [R01 AR049126, R01 AR049126-07] Funding Source: Medline
The present study was undertaken to deter-mine whether germline encoded and polyreactive antibodies might be pathogenic and whether the breach of early tolerance checkpoints in systemic lupus erythematosus (SLE) might lead to a population of B cells expressing germline encoded antibodies that become pathogenic merely by class switching to IgG in a pro-inflammatory milieu. We demonstrate here that IgM, DNA-reactive antibodies obtained from lupus patients that are unmutated and display polyreactivity can bind to isolated glomeruli and exhibit neurotoxic potential. Thus, the IgM polyreactive repertoire in SLE includes antibodies that may acquire pathogenic function merely by undergoing class-switch recombination to become IgG antibodies. (C) 2009 Elsevier Ltd. All rights reserved.
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