期刊
NATURE REVIEWS MICROBIOLOGY
卷 13, 期 7, 页码 403-413出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro3449
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- UK Medical Research Council
- European Commission
- Wellcome Trust
- US National Institutes of Health
- Department of Health via a UK National Institute for Health Research comprehensive Biomedical Research Centre award
- King's College London
- King's College Hospital NHS Foundation Trust
- Medical Research Council [G0401570, G1001081, G1000196, MR/M001199/1] Funding Source: researchfish
- Wellcome Trust [106223/Z/14/Z] Funding Source: researchfish
- MRC [G1001081, G0401570, G1000196, MR/M001199/1] Funding Source: UKRI
The ability of interferons (IFNs) to inhibit HIV-1 replication in cell culture models has long been recognized, and the therapeutic administration of IFN alpha to HIV-1-infected patients who are not receiving antiretroviral therapy produces a clear but transient decrease in plasma viral load. Conversely, studies of chronic HIV-1 infection in humans and SIV-infected animal models of AIDS show positive correlations between elevated plasma levels of IFNs, increased expression of IFN-stimulated genes (ISGs), biomarkers of inflammation and disease progression. In this Review, we discuss the evidence that IFNs can control HIV-1 replication in vivo and debate the controversial role of IFNs in promoting the pathological sequelae of chronic HIV-1 infection.
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