期刊
JOURNAL OF AUTOIMMUNITY
卷 31, 期 3, 页码 281-287出版社
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jaut.2008.04.018
关键词
Antibody; Autoimmunity; Central nervous system; Demyelination; Inflammation; Multiple sclerosis; Myelin proteolipid protein; Post-translational modification; T cell
类别
Myelin proteolipid protein (PLP) is the most abundant protein in central nervous system (CNS) myelin and plays a major role in maintaining the structural and functional integrity of myelin. Its abundance in, and restriction to, CNS myelin and its post-translational modification by acylation make PLIP an effective autoantigen, which can induce experimental autoimmune encephalomyelitis in rodents and non-human primates and which is a target of pathogenic autoimmunity in people with multiple sclerosis, a chronic inflammatory demyelinating CNS disease. (C) 2008 Elsevier Ltd. All rights reserved.
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