期刊
NATURE REVIEWS GENETICS
卷 16, 期 2, 页码 71-84出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3863
关键词
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资金
- US National Science Foundation Graduate Research Fellowship Program
- US National Institutes of Health
Diverse classes of RNA, ranging from small to long non-coding RNAs, have emerged as key regulators of gene expression, genome stability and defence against foreign genetic elements. Small RNAs modify chromatin structure and silence transcription by guiding Argonaute-containing complexes to complementary nascent RNA scaffolds and then mediating the recruitment of histone and DNA methyltransferases. In addition, recent advances suggest that chromatin-associated long non-coding RNA scaffolds also recruit chromatin-modifying complexes independently of small RNAs. These co-transcriptional silencing mechanisms form powerful RNA surveillance systems that detect and silence inappropriate transcription events, and provide a memory of these events via self-reinforcing epigenetic loops.
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