期刊
NATURE REVIEWS GENETICS
卷 16, 期 8, 页码 459-471出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg3922
关键词
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资金
- Innovative Medicines Initiative [115583]
- European Union
- EFPIA company
- Vetenskapsradet (Swedish Science Council)
- EU (EvoTar project)
Drug therapy has a crucial role in the treatment of viral, bacterial, fungal and protozoan infections, as well as the control of human cancer. The success of therapy is being threatened by the increasing prevalence of resistance. We examine and compare mechanisms of drug resistance in these diverse biological systems (using HIV and Plasmodium falciparum as examples of viral and protozoan pathogens, respectively) and discuss how factors-such as mutation rates, fitness effects of resistance, epistasis and clonal interference-influence the evolutionary trajectories of drug-resistant clones. We describe commonalities and differences related to resistance development that could guide strategies to improve therapeutic effectiveness and the development of a new generation of drugs.
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