期刊
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
卷 18, 期 7, 页码 592-595出版社
JAPAN ATHEROSCLEROSIS SOC
DOI: 10.5551/jat.7625
关键词
Adiponectin; Fat distribution; Visceral obesity
Aim: Most studies have reported that circulating levels of adiponectin are negatively correlated with the body mass index (BMI), and hypoadiponectinemia is related to cardiometabolic disorders; however, not all obese subjects have hypoadiponectinemia. The present study investigated circulating adiponectin levels and fat distribution, i.e. subcutaneous fat area (SFA) and visceral fat area (VFA), in obese subjects. Methods: Sixty-eight obese Korean subjects underwent fat distribution by computed tomography (CT) scan and laboratory tests including circulating total adiponectin levels (APN) and circulating high molecular weight adiponectin levels (HMW-APN). Results: Log-APN and log-HMW-APN did not correlate with log-BMI either in obese males or females in this study; however, log-APN significantly and negatively correlated with log-VFA both in obese males (r = -0.691, p = 0.009) and females (r = -0.319, p = 0.002), and log-HMW-APN also correlated negatively with log-VFA both in obese males (r = -0.650, p = 0.016) and females (r = -0.370, p = 0.005). Log-VFA was a significant determinant of log-APN and log-HMW-APN in obese subjects. In contrast, neither log-APN nor log-HMW-APN was significantly correlated with log-SFA in obese males and females. Conclusions: The present study demonstrated that APN and HMW-APN correlated with VFA, but not BMI and SFA, in obese subjects, and suggest that hypoadiponectinemia may represent dysfunction of adipose tissue in obesity.
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