期刊
NATURE REVIEWS ENDOCRINOLOGY
卷 12, 期 1, 页码 43-60出版社
NATURE RESEARCH
DOI: 10.1038/nrendo.2015.181
关键词
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资金
- Heart and Stroke Foundation of Canada research fellowship award
- China Scholarship Council
- CARIGEST SA.
- Fondation Romande pour la Recherche sur le Diabete, Switzerland
- Ecole Polytechnique Federale de Lausanne
- National Institutes of Health [R01AG043930]
- Swiss National Science Foundation [31003A-124713]
- Systems X [51RTPO-151019]
- Krebsforschung Schweiz [KFS-3082-02-2013]
- NATIONAL INSTITUTE ON AGING [R01AG043930] Funding Source: NIH RePORTER
Reversible acetylation was initially described as an epigenetic mechanism regulating DNA accessibility. Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolism, circadian rhythm and cell cycle, along with gene regulation in various organisms. The widespread and reversible nature of acetylation also revitalized interest in the mechanisms that regulate lysine acetyltransferases (KATs) and deacetylases (KDACs) in health and disease. Changes in protein or histone acetylation are especially relevant for many common diseases including obesity, diabetes mellitus, neurodegenerative diseases and cancer, as well as for some rare diseases such as mitochondrial diseases and lipodystrophies. In this Review, we examine the role of reversible acetylation in metabolic control and how changes in levels of metabolites or cofactors, including nicotinamide adenine dinucleotide, nicotinamide, coenzyme A, acetyl coenzyme A, zinc and butyrate and/or beta-hydroxybutyrate, directly alter KAT or KDAC activity to link energy status to adaptive cellular and organismal homeostasis.
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