期刊
JOURNAL OF ASTHMA
卷 50, 期 9, 页码 983-989出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/02770903.2013.832293
关键词
Air pollution; asthma; airway inflammation; eosinophilic; induced sputum; neutrophilic; older adults
资金
- NIH/NCRR [8 KL2 TR000078-05]
- NIEHS [P30-ES006096]
- USPHS [UL1 RR026314]
Objective: Airway inflammatory patterns in older asthmatics are poorly understood despite high asthma-related morbidity and mortality. In this study, we sought to define the relationship between exposure to traffic pollutants, biomarkers in induced sputum, and asthma control in older adults. Methods: Induced sputum was collected from 35 non-smoking adults <= 65 years with a physician's diagnosis of asthma and reversibility with a bronchodilator or a positive methacholine challenge. Patients completed the Asthma Control Questionnaire (ACQ), and Elemental Carbon Attributable to Traffic (ECAT), a surrogate for chronic diesel particulate exposure, was determined. Equal numbers of subjects with high (>= 0.39 mg/m(3)) versus low (50.39 mg/m(3)) ECAT were included. Differential cell counts were performed on induced sputum, and myeloperoxidase (MPO) and eosinophil peroxidase (EPO) were measured in supernatants. Regression analyses were used to evaluate the relationship between sputum findings, ACQ scores, and ECAT. Results: After adjustment for potential confounders, subjects with poorly controlled asthma based on ACQ >= 1.5 (n=7) had significantly higher sputum eosinophils (median 4.4%) than those with ACQ51.5 (n=28; eosinophils 2.6%; beta=10.1 [95% CI=0.121.0]; p=0.05). Subjects with ACQ >= 1.5 also had significantly higher sputum neutrophils (84.2% versus 65.2%; beta=7.1 [0.2-14.6]; p =0.05). Poorly controlled asthma was associated with higher sputum EPO (=2.4 [0.2-4.5], p=0.04), but not MPO (p=0.9). High ECAT was associated with higher eosinophils (=10.1 [1.8-18.4], p=0.02) but not higher neutrophils (p 0.6). Conclusions: Poorly controlled asthma in older adults is associated with eosinophilic and neutrophilic inflammation. Chronic residential traffic pollution exposure may be associated with eosinophilic, but not neutrophilic inflammation in older asthmatics.
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