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The GLUT9 gene is associated with serum uric acid levels in Sardinia and chianti cohorts
Siguang Li et al.
PLOS GENETICS (2007)
Tetrapeptide inhibitors of the glutamate vesicular transporter (VGLUT)
Sarjubhai A. Patel et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)
LeuT-desipramine structure reveals how antidepressants block neurotransmitter reuptake
Zheng Zhou et al.
SCIENCE (2007)
Cheerful news for antidepressant research
Simon Hadlington
CHEMISTRY WORLD (2007)
Antidepressant binding site in a bacterial homologue of neurotransmitter transporters
Satinder K. Singh et al.
NATURE (2007)
Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action
Shingo Sakamoto et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
Laura J. Scott et al.
SCIENCE (2007)
A high-throughput screen for aggregation-based inhibition in a large compound library
Brian Y. Feng et al.
JOURNAL OF MEDICINAL CHEMISTRY (2007)
A genome-wide association study identifies novel risk loci for type 2 diabetes
Robert Sladek et al.
NATURE (2007)
Glucose-6-phosphate transporter gene therapy corrects metabolic and myeloid abnormalities in glycogen storage disease type Ib mice
W. H. Yiu et al.
GENE THERAPY (2007)
Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: Novel pathways and targets for anticancer therapeutics
Rachel E. Airley et al.
CHEMOTHERAPY (2007)
Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level
Kenji Katsuno et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2007)
Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia
Marjorie J. Lindhurst et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors
Hiroshi Nawashiro et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Apical sodium dependent bile acid transporter (ASBT, SLC10A2): A potential prodrug target
Anand Balakrishnan et al.
MOLECULAR PHARMACEUTICS (2006)
Monocarboxylate transporter MCT1 is a target for immunosuppression
CM Murray et al.
NATURE CHEMICAL BIOLOGY (2005)
The substituted aspartate analogue L-β-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3
CS Esslinger et al.
NEUROPHARMACOLOGY (2005)
Glutamate Transporters as Drug Targets
Eiichi Hinoi et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2005)
Inhibitors of the glutamate vesicular transporter (VGLUT)
CM Thompson et al.
CURRENT MEDICINAL CHEMISTRY (2005)
The SLC22 drug transporter family
H Koepsell et al.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2004)
A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese
N Iwai et al.
KIDNEY INTERNATIONAL (2004)
Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice
H Guo et al.
HUMAN MOLECULAR GENETICS (2003)
Islet β-cell secretion determines glucagon release from neighbouring α-cells
H Ishihara et al.
NATURE CELL BIOLOGY (2003)
Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice
A Schmitt et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2003)
Insights into glutamate transport regulation in human astrocytes: Cloning of the promoter for excitatory amino acid transporter 2 (EAAT2)
ZZ Su et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Amish lethal microcephaly: A new metabolic disorder with severe congenital microcephaly and 2-ketoglutaric aciduria
RI Kelley et al.
AMERICAN JOURNAL OF MEDICAL GENETICS (2002)
Mutant deoxynucleotide carrier is associated with congenital microcephaly
MJ Rosenberg et al.
NATURE GENETICS (2002)
The druggable genome
AL Hopkins et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
Synthesis and in vitro pharmacology of substituted quinoline-2,4-dicarboxylic acids as inhibitors of vesicular glutamate transport
CN Carrigan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Further insight into mechanism of action of clodronate:: Inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite
PP Lehenkari et al.
MOLECULAR PHARMACOLOGY (2002)
Increased [H-3]tiagabine binding to GAT-1 in the cingulate cortex in schizophrenia
I Sundman-Eriksson et al.
NEUROPSYCHOBIOLOGY (2002)
Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc- cystine transporter:: a new action for an old drug
PW Gout et al.
LEUKEMIA (2001)
Zinc as a paracrine effector in pancreatic islet cell death
BJ Kim et al.
DIABETES (2000)
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