期刊
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
卷 28, 期 7, 页码 591-596出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-011-9564-2
关键词
Metformin; Orlistat; PCOS; Weight loss; Waist circumference
资金
- Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences and Sabzevar University of Medical Sciences, Sabzevar, Iran
Purpose Comparing the effects of metformin or orlistat on hormone, lipid profile and ovulation status in obese women with polycystic ovary syndrome. Methods A total of 80 women were prospectively recruited to receive either metformin (n = 40) or orlistat (n = 40). Weight, BMI, waist, serum LH, total serum testosterone and lipid profile were assessed at baseline and after 3 months. The subjects' ovulatory status was assessed after 3 months. Results There was no significant difference in ovulation between the two treatment groups (30% vs 15%). Treatment with either drug showed a significant decline in body weight, BMI (Body Mass Index), and waist circumference, but the degree of decline in both groups was the same. Patients who were treated with orlistat, showed a significant reduction in total testosterone and serum lipid. Women in metformin group showed a significant reduction in serum LH. Conclusions Both metformin and orlistat showed a similar effect on weight loss and ovulation rates.
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