期刊
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
卷 28, 期 7, 页码 583-589出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-011-9553-5
关键词
Premature ovarian failure; Nobox; Homeobox; Ovary; Germ cells
资金
- National Institutes of Health [HD44858, HD058125]
- 413 March of Dimes grant [6-FY08-313]
Purpose To understand the mechanism of premature ovarian failure (POF). Methods The ultrastructural (electron microscopy) analysis of primordial ovarian follicles in Nobox deficient mice. Results We studied, for the first time, the fate of oogonia in embryonic (prenatal) mouse ovaries and showed that the abolishment of the transition from germ cell cysts to primordial follicles in the ovaries of Nobox deficient mice is caused by defects in germ cell cyst breakdown, leading to the formation of syncytial follicles instead of primordial follicles. Conclusions These results indicate that POF syndrome in Nobox deficient mice results from the faulty signaling between somatic and germ line components during embryonic development. In addition, the extremely unusual and abnormal presence of adherens junctions between unseparated oocytes within syncytial follicles indicates that faulty communication between somatic and germ cells is involved in, or leads to, abnormalities in the cell adhesion program.
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