期刊
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
卷 26, 期 9-10, 页码 537-544出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10815-009-9346-2
关键词
Antioxidant; DNA methylation; Homocysteine; Sperm
资金
- The Colin Matthews Research Fund (University of Adelaide)
- Bayer Consumer Care, Australia
- The University of Adelaide
Methylation of sperm DNA is impaired in many infertile men potentially adversely effecting reproductive outcomes. In somatic cells oxidative damage to DNA and hyperhomocysteinaemia are linked with DNA hypomethylation. The objective of this study was to investigate if these pathologies also impair sperm DNA methylation. The relationship between sperm DNA quality, oxidative stress and serum homocysteine was analysed at study entry and after 3 months of antioxidant treatment. Overall a significant negative correlation was observed between sperm DNA methylation and sperm DNA fragmentation, as well as seminal reactive oxygen species (ROS) production. Sperm DNA methylation was not significantly related to serum homocysteine concentrations. Administration of an antioxidant supplement produced a significant fall in seminal ROS levels and sperm DNA fragmentation, while increasing sperm DNA methylation. These results suggest that oxidative stress related damage to sperm DNA impedes the process of methylation, while antioxidant supplementation appears to have the potential to reduce DNA damage and normalize sperm DNA methylation.
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