Intrauterine insemination: is the timing correct?

Objective To evaluate the impact of follicle rupture on pregnancy rate in intrauterine insemination. Material and method Retrospective cohort study. Evidence of follicle rupture was assessed by transvaginal ultrasonography following IUI. Two hundred ninety-six couples with unexplained infertility and 121 couples with male factor subfertility were included. Results of 578 cycles were analyzed here. Result Clinical pregnancy rate was 23.5% (64/272) in the group when follicle rupture was evident by transvaginal ultrasonography, while it was only 8.8% (27/306) when follicle rupture was not evident (p < 0.001). Conclusion Postponing IUI until observation of follicle rupture may yield a higher pregnancy rate.